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KMID : 0606920110190040472
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Biomolecules & Therapeutics
2011 Volume.19 No. 4 p.472 ~ p.476
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Effect of Yacon on Platelet Function in Hypercholesterolemic Rabbits
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Lim Yong
Son Dong-Ju
Kim Yun-Bae
Hwang Bang-Yeon
Yun Yeo-Pyo
Hwang Seock-Yeon
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Abstract
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Hypercholesterolemia indirectly increases the risk of arterial and venous thrombosis by enhancing the ability of platelets to ag-gregate. Yacon (Smallanthus sonchifolius) is composed of fructooligosaccharides, proteins, minerals and phenolic compounds, and has potential benefi ts for the management of diabetes. This study investigated whether the consumption of yacon in the diet inhibits platelet aggregation under hypercholesterolemic conditions. Male New Zealand white rabbits were fed one of fi ve dietary interventions: a normal control diet, 0.5% cholesterol diet, 0.5% cholesterol diet+a low dose of yacon (0.5 g/kg body weight given orally each day), 0.5% cholesterol diet+a high dose of yacon (2.5 g/kg body weight given orally each day), or a 0.5% cholesterol diet+lovastatin (2 mg/kg body weight given orally each day). After 8 weeks, blood was collected to measure the amount of col-lagen- and thrombin-induced platelets present. Yacon inhibited the platelet aggregation induced by low doses of agonists (0.5 ?g/ml collagen and 0.02 units/ml thrombin) in a concentration-dependent manner. In addition, yacon concentration-dependently inhibited collagen-induced arachidonic acid liberation. Moreover, n-hexane, chloroform and ethyl acetate fractions showed a marked and selective inhibition of the platelet aggregation induced by collagen, again in a dose-dependent manner. These frac-tions, especially that of chloroform, signifi cantly suppressed platelet aggregation. The results of this study demonstrate that when yacon is added to a cholesterol-enriched diet, cholesterol-induced platelet aggregation returns to control levels. This may also be benefi cial in preventing atherosclerosis and reducing risk factors for coronary artery disease and stroke.
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KEYWORD
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Antiplatelet, Yacon, Hypercholesterolemia, Thrombosis
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